Clinical FAQ — Erectile Dysfunction
This guide explains how ED medications work for erectile dysfunction and what to expect from treatment.
MedExpress offers several treatment options, including tablets taken on demand before sexual activity, daily tablets, and chewable tablets. All work by improving blood flow to help you achieve and maintain an erection when sexually aroused.
Use this guide when you need to:
Understand what ED medications are and how they work
Learn about the different treatment options available through MedExpress
Understand the difference between on-demand and daily treatment
Check whether these medications are safe
What is erectile dysfunction?
Erectile dysfunction (ED) is the inability to get or keep an erection that is firm enough for satisfactory sexual activity. ED is very common and can affect men of all ages, though it becomes more common with age.
ED can be caused by physical factors (such as cardiovascular conditions, diabetes, or hormonal changes), psychological factors (such as stress, anxiety, or depression), or a combination of both.
What are PDE5 inhibitors?
The medications prescribed by MedExpress for erectile dysfunction belong to a class called phosphodiesterase type 5 (PDE5) inhibitors.
PDE5 inhibitors work by helping to relax the blood vessels in the penis when you are sexually aroused. This allows increased blood flow into the penis to help you achieve and maintain an erection.
Important: these medications work only with sexual stimulation. They do not cause spontaneous erections and they do not increase sex drive or libido.
What treatment options does MedExpress offer?
MedExpress offers four types of ED treatment:
Sildenafil — on-demand tablets
Sildenafil is taken 30 to 60 minutes before sexual activity. It typically lasts for 4 to 6 hours. Available as both brand-name and generic tablets. Sildenafil is one of the most widely prescribed ED medications, with extensive clinical evidence supporting its use.
Tadalafil — on-demand tablets
Tadalafil on-demand is taken 30 to 60 minutes before sexual activity. It can remain effective for up to 36 hours, providing a longer window of opportunity compared to sildenafil. Available as both brand-name and generic tablets.
Tadalafil — daily tablets
Tadalafil daily is taken once every day at approximately the same time, regardless of when sexual activity is planned. Because the medication is always active in your system, you do not need to plan around a dose. This option is suitable for men who prefer spontaneity or who have frequent sexual activity. Available as both brand-name and generic tablets.
Sildenafil and Tadalafil chewable tablets
MedExpress also offers chewable tablets that combine sildenafil and tadalafil. These mint-flavoured chewable tablets are designed to provide both the rapid onset of sildenafil and the longer-lasting effects of tadalafil. Available in daily and on-demand strengths.
Quick comparison: which option suits your lifestyle?
Your clinician will recommend the most suitable option based on your consultation. The table below can help you think about what might suit your lifestyle.
| Sildenafil | Tadalafil on-demand | Tadalafil daily |
Takes effect | 30–60 min | 30–60 min | After ~5 days |
Window | 4–6 hours | Up to 36 hours | Always active |
Best for | Simple, proven option | Flexible timing | No planning needed |
How do these medications help with erectile dysfunction?
PDE5 inhibitors work across multiple systems in your body.
Key effects include:
Blood vessels: Relax smooth muscle in the penis, allowing increased blood flow
Nervous system: Enhance the natural erectile response to sexual stimulation
Sustained effect: Help maintain the erection by preventing the breakdown of a chemical called cGMP
These effects help you:
Achieve a firmer erection when sexually aroused
Maintain the erection for longer during sexual activity
Feel more confident and less anxious about sexual performance
Are ED medications safe?
Yes. The ED medications offered by MedExpress are:
Clinically tested and approved for use in Canada
Prescribed by Canadian-licensed healthcare professionals
Provided only after a full clinical assessment
MedExpress ensures that:
Your medical history is reviewed before prescribing
The medication is appropriate and safe for your individual circumstances
Ongoing clinical support is available during treatment
Important: MedExpress clinical assessment
MedExpress provides an online consultation where a licensed clinician determines whether ED treatment is suitable for you.
MedExpress will only prescribe ED medication if:
The treatment is clinically appropriate
The benefits outweigh any potential risks
If you still need help after reviewing the information above, additional assistance is available.