This guide explains exactly how to inject Wegovy, Mounjaro, Ozempic, and Zepbound using their injection pens.
Each weight loss medication uses a different pen type (multi-dose), so it’s important to follow the correct instructions for your specific medication.
Use this guide when you need to:
Learn how to inject your weight loss medication step by step
Understand how Wegovy, Mounjaro, Ozempic, or Zepbound pens work
Avoid common injection mistakes
Know what to do if your injection does not work properly
How do I inject Wegovy? (Multi-dose injection pen)
Wegovy® uses a multi-dose prefilled pen (The FlexTouch pen), which means you must dispose of the entire Wegovy pen after one injection.
Keep the Wegovy pen between weekly injections and attach a new needle for each injection. Each Wegovy pen contains 4 weekly doses.
Wegovy is supplied in 5 different pen strengths (0.25 mg, 0.5 mg, 1 mg, 1.7 mg, and 2.4 mg per week), each with a different coloured cap. Your pen has been set to deliver your prescribed weekly dose - you do not need to adjust the dose yourself.
Step-by-step Wegovy injection instructions
Wash your hands thoroughly.
Check that the medication in the Wegovy pen is clear and colourless. Do not use the pen if the solution is cloudy or contains particles.
Clean the injection site using an alcohol swab.
Attach a new needle to the Wegovy pen and remove both needle caps.
If using a new Wegovy pen for the first time, check the flow as described in the leaflet inside your pen packaging.
Insert the needle into your skin in your abdomen, thigh, or upper arm.
Press and hold the injection button until the dose counter shows 0.
Keep the needle in your skin and count slowly to 6 before removing the needle.
Remove the needle from your skin.
Detach the needle and dispose of it in a sharps container.
Replace the cap on the Wegovy pen and store the pen safely until your next dose
Important: Wegovy pens are multi-dose, so:
You keep the Wegovy pen after each use
You must use a new needle for every injection
Discard the Wegovy pen after 4 weekly doses, or as instructed in your leaflet
For a step-by-step demonstration, see the Wegovy injection video guide, which shows how to use the Wegovy® pen correctly.
How do I inject Mounjaro? (Multi-dose KwikPen)
Mounjaro uses a multi-dose prefilled pen called the KwikPen®, which is kept between weekly injections. Each Mounjaro KwikPen contains 4 weekly doses, and you attach a new needle for each injection.
Mounjaro is supplied in 6 different KwikPen strengths (2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg per week). Your KwikPen has been set to deliver your prescribed weekly dose.
Step-by-step Mounjaro injection instructions
Wash your hands thoroughly.
Check that the medication in the Mounjaro KwikPen is clear and colourless to slightly yellow. Do not use the pen if the solution is cloudy, discoloured, or contains particles.
Clean the injection site using an alcohol swab.
Attach a new needle to the Mounjaro KwikPen.
Choose your injection site (abdomen, thigh, or back of the upper arm if given by someone else) and place the KwikPen straight against your skin.
Unlock the Mounjaro KwikPen by turning the lock ring if your device has this feature.
Press the purple injection button on the Mounjaro KwikPen to start the injection.
Hold the Mounjaro KwikPen in place until you hear or feel the second click, which confirms the injection is complete (about 5 to 10 seconds).
Remove the Mounjaro KwikPen from your skin.
Detach the needle and dispose of it in a sharps container.
Replace the cap on the Mounjaro KwikPen and store the pen safely until your next dose
Important: Mounjaro KwikPens are multi-dose, so:1. You keep the KwikPen after each use
2. You must use a new needle for every injection
3. Discard the KwikPen after 4 weekly doses (approximately 30 days)
4. Never share your KwikPen with another person, even if the needle is changed
For a step-by-step demonstration, see the Mounjaro injection video guide, which shows how to use the Mounjaro® pen.
How do I inject Ozempic? (Multi-dose injection pen with needle)
Ozempic uses a multi-dose injection pen, which means you keep the Ozempic pen and attach a new needle for each injection.
Step-by-step Ozempic injection instructions
Wash your hands thoroughly.
Clean the injection site using an alcohol swab.
Attach a new needle to the Ozempic pen and remove both needle caps.
If using a new Ozempic pen for the first time, check the flow by turning the selector until a drop appears at the needle tip.
Turn the dose selector on the Ozempic pen to your prescribed dose.
Insert the needle into your skin.
Press and hold the injection button until the dose counter returns to 0.
Keep the needle in your skin and count slowly to 6 before removing the needle.
Remove the needle and dispose of the needle in a sharps container.
Replace the cap on the Ozempic pen and store the Ozempic pen safely.
Important: Ozempic pens are multi-dose, so:
You keep the Ozempic pen after each use
You must use a new needle for every injection
For a step-by-step demonstration, see the Ozempic injection video guide, which shows how to use the Ozempic® pen correctly.
How do I inject Zepbound? (Multi-dose KwikPen)
Zepbound uses a multi-dose prefilled pen called the KwikPen®, similar to the Mounjaro® pen. The Zepbound KwikPen uses the same device as Mounjaro. Each KwikPen contains 4 weekly doses, and you attach a new needle for each injection.
Zepbound is supplied in 6 different KwikPen strengths (2.5 mg, 5 mg, 7.5 mg, 10 mg, 12.5 mg, and 15 mg per week). Your KwikPen has been set to deliver your prescribed weekly dose.
Step-by-step Zepbound injection instructions
Wash your hands thoroughly.
Check that the medication in the Zepbound KwikPen is clear and colourless to slightly yellow. Do not use the pen if the solution is cloudy, discoloured, or contains particles.
Clean the injection site using an alcohol swab.
Attach a new needle to the Zepbound KwikPen.
Choose your injection site (abdomen, thigh, or back of the upper arm if given by someone else) and place the KwikPen flat against your skin.
Unlock the Zepbound KwikPen if your device includes a lock feature.
Press the injection button on the Zepbound KwikPen to start the injection.
Hold the Zepbound KwikPen in place until you hear or feel the click that confirms the injection is complete (about 5 to 10 seconds).
Remove the Zepbound KwikPen from your skin.
Detach the needle and dispose of it in a sharps container.
Replace the cap on the Zepbound KwikPen and store the pen safely until your next dose.
Important: Zepbound KwikPens are multi-dose, so:
You keep the KwikPen after each use
You must use a new needle for every injection
Discard the KwikPen after 4 weekly doses (approximately 30 days)
Never share your KwikPen with another person, even if the needle is changed
For a step-by-step demonstration, see the Zepbound injection video guide, which shows how to use the Zepbound pen.
How do I inject generic semaglutide? (Multi-dose injection pen with needle)
Generic semaglutide (such as Apo-Semaglutide) uses a multi-dose injection pen, similar to the Ozempic pen. You keep the pen and attach a new needle for each injection.
Generic semaglutide is available in two pen types:
A 0.25 mg / 0.5 mg pen with dose markers for both doses (used for starting and titration)
A 1 mg pen that delivers 1 mg per injection
Step-by-step generic semaglutide injection instructions
Wash your hands thoroughly.
Clean the injection site using an alcohol swab.
Attach a new needle to the generic semaglutide pen and remove both needle caps.
If using a new generic semaglutide pen for the first time, check the flow by turning the selector until a drop appears at the needle tip.
Turn the dose selector on the generic semaglutide pen to your prescribed dose.
Insert the needle into your skin.
Press and hold the injection button until the dose counter returns to 0.
Keep the needle in your skin and count slowly to 6 before removing the needle.
Remove the needle and dispose of the needle in a sharps container.
Replace the cap on the generic semaglutide pen and store the pen safely.
Important: Generic semaglutide pens are multi-dose, so:
You keep the pen after each use
You must use a new needle for every injection
Note on doses above 1 mg per week: Generic semaglutide pens currently deliver a maximum of 1 mg per injection. If your prescribed weekly dose is higher than 1 mg, you will need to give yourself more than one injection per week. See the Dosing & Treatment article for full multi-injection guidance.
Note on pen presentation: If your generic semaglutide pen looks different from a previous order, this may be because the product has been supplied by a different manufacturer. The active ingredient and dose are the same. Always check the strength on the packaging and follow the instructions provided with your specific pen. If you are unsure, do not inject and contact our clinical support team.
Where should I inject Wegovy, Mounjaro, Ozempic, Zepbound, or generic semaglutide?
All medications listed above (Wegovy, Mounjaro, Ozempic, Zepbound, and generic semaglutide) should be injected into one of the following areas:
Abdomen (stomach area)
Thigh
Upper arm
Injection site tips
Rotate the injection site each week to reduce irritation
Do not inject into skin that is bruised, red, or tender
Use the same day each week for your injection
If you need to change your dosing day, leave at least 3 days (72 hours) between two doses
When should I contact a healthcare professional?
Contact a healthcare professional if:
You are unsure whether the full dose of Wegovy, Mounjaro, Ozempic, Zepbound, or generic semaglutide was delivered
The injection pen does not activate or malfunctions
You experience severe pain, swelling, or unusual side effects after injection
If you still need help after reviewing the information above, additional assistance is available.